Hello NL!:
So you say that Steam version works fine to play coop or any of the other game modes online?? Curious and interesting!... in the Steam store game page it says "multiplayer is not supported"... If you confirm that works just fine as it should be, I can seriously consider to buy it! But forgive me if I say this, but I'll not spend a single penny in a game that doesn't support online modes when back in time it does

(that would be disappointing!)
Well yes, I have steam installed in my system, but there's no any relation between my game and Steam (if I played startin' H&D2 from Steam library if that's what you mean...) In fact, I have Steam many years ago when I played games like L4D, L4D2 (Left 4 Dead saga), Killing Floor, etc... I always run H&D2 completely separate.
Who knows!?... maybe is Windows 10, maybe is Windows Defender (integrated in W10)... Maybe it's also because I have closed many (mostly those considered obsolete by many internet sources) Windows services in order to give my computer better performance without running stuffs in background... I don't know, but as I said before, on Windows 7 happens the same things (tested on my bro's PC and my mom's PC)... that's strange...
Cheers mate!! good luck in your future test... we keeping up to date